| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 4/18/1946 | BoN | Konstanty | Acquired via trade | Cin | | Before |
| 4/18/1946 | BoN | Sisti | Demoted to reserve roster | | | Before |
| 4/18/1946 | BoN | West | Traded away | Cin | | Before |
| 4/18/1946 | Brk | Ramazzotti | Promoted to active roster | | | Before |
| 4/18/1946 | Cin | West | Acquired via trade | BoN | | Before |
| 4/19/1946 | BoN | McCarthy | Demoted to reserve roster | | | Before |
| 4/19/1946 | ChA | Platt | Acquired via trade | ChN | | Before |
| 4/20/1946 | Pit | Lopez | Placed on disabled list | | | Before |
| 4/22/1946 | Brk | Corriden | Demoted to reserve roster | | | Before |
| 4/22/1946 | Cin | Moss | Promoted to active roster | | | Before |
| 4/23/1946 | Brk | Naylor | Acquired via trade | SLN | | Before |
| 4/23/1946 | ChA | O'Neill | Acquired via trade | ChN | | Before |
| 4/23/1946 | ChN | O'Neill | Traded away | ChA | | Before |
| 4/23/1946 | ChN | Prim | Placed on disabled list | | | Before |
| 4/23/1946 | NYN | Kraus | Acquired via trade | PhN | | Before |
| 4/23/1946 | SLA | Dahlgren | Acquired via trade | Pit | | Before |
| 4/24/1946 | NYA | Drews | Demoted to reserve roster | | | Before |
| 4/24/1946 | NYA | Karpel | Demoted to reserve roster | | | Before |
| 4/24/1946 | Pit | Clemensen | Demoted to reserve roster | | | Before |
| 4/25/1946 | PhN | Dinges | Demoted to reserve roster | | | Before |
| 4/26/1946 | BoN | Detweiler | Demoted to reserve roster | | | Before |
| 4/26/1946 | NYN | Adams | Suspended | | | Before |
| 4/26/1946 | NYN | Feldman | Suspended | | | Before |
| 4/27/1946 | Brk | Riggs | Released | | | Before |
| 4/27/1946 | Cle | Sepkowski | Demoted to reserve roster | | | Before |
| 4/27/1946 | Pit | Anderson | Demoted to reserve roster | | | Before |
| 4/28/1946 | Brk | Graham | Traded away | NYN | | Before |
| 4/28/1946 | Brk | Rosen | Traded away | NYN | | Before |
| 4/28/1946 | ChA | Baker | Demoted to reserve roster | | | Before |
| 4/28/1946 | NYN | Graham | Acquired via trade | Brk | | Before |
| 4/28/1946 | NYN | Rosen | Acquired via trade | Brk | | Before |
| 4/28/1946 | Pit | Smith | Placed on disabled list | | | Before |
| 4/29/1946 | BoN | Johnson | Signed | | | Before |
| 4/29/1946 | Det | Harris | Demoted to reserve roster | | | Before |
| 4/29/1946 | NYN | Arnovich | Demoted to reserve roster | | | Before |
| 4/29/1946 | NYN | Maynard | Demoted to reserve roster | | | Before |
| 4/29/1946 | PhN | Johnson | Released | | | Before |
| 4/29/1946 | SLA | Archie | Released | | | Before |
| 4/30/1946 | Cin | Vollmer | Demoted to reserve roster | | | Before |
| 4/30/1946 | PhA | Derry | Acquired via trade | NYA | | Before |
| 4/30/1946 | Pit | Barnhart | Demoted to reserve roster | | | Before |
| 5/1/1946 | Brk | Davis,C | Released | | | Before |
| 5/1/1946 | NYN | DiMaggio | Acquired via trade | PhN | | Before |
| 5/1/1946 | NYN | Kluttz | Traded away | SLN | | Before |
| 5/1/1946 | PhN | DiMaggio | Traded away | NYN | | Before |
| 5/1/1946 | PhN | Verban | Acquired via trade | SLN | | Before |
| 5/1/1946 | SLN | Kluttz | Acquired via trade | NYN | | Before |
| 5/1/1946 | SLN | Verban | Traded away | PhN | | Before |
| 5/2/1946 | BoN | Hutchings | Demoted to reserve roster | | | Before |
| 5/2/1946 | PhA | Vaughan | Demoted to reserve roster | | | Before |
| 5/2/1946 | PhN | Murtaugh | Demoted to reserve roster | | | Before |
| 5/3/1946 | BoN | Hendrikson | Demoted to reserve roster | | | Before |
| 5/3/1946 | BoN | Roser | Acquired via trade | NYA | | Before |
| 5/3/1946 | NYA | Roser | Traded away | BoN | | Before |
| 5/3/1946 | PhA | Garrison | Demoted to reserve roster | | | Before |
| 5/3/1946 | PhA | Stainback | Signed | | | Before |
| 5/4/1946 | ChN | Prim | Activated from disabled list | | | Before |
| 5/6/1946 | Det | Gray | Signed | | | Before |
| 5/6/1946 | PhA | Berry | Demoted to reserve roster | | | Before |
| 5/7/1946 | Brk | Moulder | Demoted to reserve roster | | | Before |
| 5/7/1946 | PhA | Benson | Demoted to reserve roster | | | Before |
| 5/7/1946 | PhN | Crawford | Demoted to reserve roster | | | Before |
| 5/7/1946 | Pit | Guintini | Demoted to reserve roster | | | Before |
| 5/8/1946 | BoA | Gilbert | Demoted to reserve roster | | | Before |
| 5/8/1946 | BoA | Klinger | Signed | | | Before |
| 5/8/1946 | BoA | Wilson | Demoted to reserve roster | | | Before |
| 5/8/1946 | BoN | Williams | Demoted to reserve roster | | | Before |
| 5/8/1946 | BoN | Poland | Demoted to reserve roster | | | After |
| 5/9/1946 | SLN | Grodzicki | Placed on disabled list | | 5/8/1946 | Before |
| 5/10/1946 | NYA | Niarhos | Demoted to reserve roster | | | Before |
| 5/10/1946 | SLN | Wilber | Demoted to reserve roster | | | Before |
| 5/11/1946 | Brk | Barney | Promoted to active roster | | | Before |
| 5/11/1946 | ChN | Glossop | Demoted to reserve roster | | | Before |
| 5/11/1946 | ChN | Hanyzewski | Demoted to reserve roster | | | Before |
| 5/11/1946 | Det | Bloodworth | Promoted to active roster | | | Before |
| 5/11/1946 | Det | Gentry | Demoted to reserve roster | | | Before |
| 5/13/1946 | BoA | Deutsch | Demoted to reserve roster | | | Before |
| 5/13/1946 | NYN | Carden | Signed | | | Before |
| 5/13/1946 | PhN | Burich | Promoted to active roster | | | Before |
| 5/14/1946 | NYN | Thompson | Signed | | | Before |
| 5/15/1946 | BoN | White | Signed | | | Before |
| 5/15/1946 | Cle | Podgajny | Demoted to reserve roster | | | Before |
| 5/15/1946 | PhA | Konopka | Demoted to reserve roster | | | Before |
| 5/15/1946 | PhN | Hemsley | Placed on disabled list | | | After |
| 5/16/1946 | Cin | Moss | Demoted to reserve roster | | | Before |
| 5/16/1946 | Det | Hitchcock | Traded away | Was | | Before |
| 5/16/1946 | NYA | Metheny | Demoted to reserve roster | | | Before |
| 5/16/1946 | NYN | Emmerich | Demoted to reserve roster | | | Before |
| 5/16/1946 | Was | Hitchcock | Acquired via trade | Det | | Before |
| 5/17/1946 | Pit | Gornicki | Promoted to active roster | | | Before |
| 5/18/1946 | Brk | Melton | Promoted to active roster | | | Before |
| 5/18/1946 | Brk | Naylor | Demoted to reserve roster | | | Before |
| 5/18/1946 | Det | Kell | Acquired via trade | PhA | | Before |
| 5/18/1946 | Det | McCosky | Traded away | PhA | | Before |
| 5/18/1946 | NYN | Brewer | Demoted to reserve roster | | | Before |
| 5/18/1946 | PhA | Kell | Traded away | Det | | Before |
| 5/18/1946 | PhA | Knott | Released | | | Before |
| 5/18/1946 | PhA | McCosky | Acquired via trade | Det | | Before |
| 5/18/1946 | Pit | Lopez | Activated from disabled list | | | Before |
| 5/19/1946 | BoA | Higgins | Acquired via trade | Det | | Before |
| 5/19/1946 | Det | Higgins | Traded away | BoA | | Before |
| 5/19/1946 | PhA | Brown | Demoted to reserve roster | | | Before |
| 5/20/1946 | ChN | Prim | Placed on disabled list | | | Before |
| 5/20/1946 | SLN | Garagiola | Promoted to active roster | | | Before |
| 5/20/1946 | Was | Goolsby | Demoted to reserve roster | | | Before |
| 5/20/1946 | Was | Sanford | Demoted to reserve roster | | | Before |
| 5/22/1946 | BoN | Javery | Demoted to reserve roster | | | Before |
| 5/22/1946 | NYN | Pike | Demoted to reserve roster | | | Before |
| 5/22/1946 | SLN | Klein | Placed on restricted list | | | Before |
| 5/22/1946 | SLN | Lanier | Placed on restricted list | | | Before |
| 5/22/1946 | SLN | Martin | Placed on restricted list | | | Before |
| 5/23/1946 | PhA | Besse | Demoted to reserve roster | | | Before |
| 5/24/1946 | Brk | Walker | Suspended | | | Before |
| 5/24/1946 | ChN | Merullo | Suspended | | | Before |
| 5/24/1946 | Det | Gray | Demoted to reserve roster | | | Before |
| 5/25/1946 | BoN | Detweiler | Promoted to active roster | | | Before |
| 5/25/1946 | BoN | Reid | Demoted to reserve roster | | | Before |
| 5/25/1946 | NYA | Hiller | Promoted to active roster | | | Before |
| 5/25/1946 | NYA | Johnson | Promoted to active roster | | | Before |
| 5/25/1946 | NYA | Souchock | Promoted to active roster | | | Before |
| 5/27/1946 | ChN | Becker | Demoted to reserve roster | | | Before |
| 5/27/1946 | SLN | Litwhiler | Promoted to active roster | | | Before |
| 5/29/1946 | BoA | Andres | Demoted to reserve roster | | | Before |
| 5/29/1946 | Brk | Walker | Reinstated | | | Before |
| 5/29/1946 | Cin | Lawing | Promoted to active roster | | | Before |
| 5/29/1946 | NYN | Schemer | Demoted to reserve roster | | | Before |
| 5/29/1946 | PhN | Milnar | Acquired via trade | SLA | | Before |
| 5/29/1946 | SLA | Finney | Traded away | PhN | | Before |
| 5/29/1946 | SLA | Milnar | Traded away | PhN | | Before |
| 5/29/1946 | SLA | Sundra | Released | | | Before |
| 5/30/1946 | BoA | Steiner | Demoted to reserve roster | | | Before |
| 5/30/1946 | SLA | Bradley | Demoted to reserve roster | | | Before |
| 5/31/1946 | Cle | Monaco | Demoted to reserve roster | | | Before |
| 6/1/1946 | ChN | Merullo | Reinstated | | | Before |
| 6/1/1946 | Pit | Coscarart | Demoted to reserve roster | | | Before |
| 6/2/1946 | NYA | Drescher | Demoted to reserve roster | | | Before |
| 6/3/1946 | BoN | McCormick | Acquired via trade | Cin | | Before |
| 6/3/1946 | Cin | McCormick | Traded away | BoN | | Before |
| 6/3/1946 | PhA | Newsom | Released | | | Before |
| 6/3/1946 | PhN | Richardson | Demoted to reserve roster | | | Before |
| 6/5/1946 | Cle | Brewster | Demoted to reserve roster | | | Before |
| 6/5/1946 | NYA | Stanceu | Traded away | PhN | | Before |
| 6/5/1946 | PhN | Stanceu | Acquired via trade | NYA | | Before |
| 6/5/1946 | Was | Newsom | Signed | | | Before |
| 6/6/1946 | ChA | Hollingsworth | Acquired via trade | SLA | | Before |
| 6/6/1946 | SLA | Hollingsworth | Traded away | ChA | | Before |
| 6/7/1946 | NYA | Niarhos | Promoted to active roster | | | Before |
| 6/8/1946 | Cin | Lawing | Traded away | NYN | | Before |
| 6/8/1946 | NYN | DiMaggio | Demoted to reserve roster | | | Before |
| 6/8/1946 | NYN | Lawing | Acquired via trade | Cin | | Before |
| 6/8/1946 | Pit | Hopper | Demoted to reserve roster | | | Before |
| 6/9/1946 | BoN | Litwhiler | Acquired via trade | SLN | | Before |
| 6/9/1946 | Cin | Burpo | Promoted to active roster | | | Before |
| 6/9/1946 | PhA | Fagan | Promoted to active roster | | | Before |
| 6/9/1946 | SLN | Jones | Promoted to active roster | | | Before |
| 6/9/1946 | SLN | Litwhiler | Traded away | BoN | | Before |